Sodium taurolithocholate( —— )

Catalog No. M19644 CAS No. 6042-32-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Sodium taurolithocholate
Note

Research use only, not for human use.
Brief Description

The major human metabolite a bile acid which inhibits radioligand binding to muscarinic M1 but not to M2 or M3 receptors.
Description

The major human metabolite a bile acid which inhibits radioligand binding to muscarinic M1 but not to M2 or M3 receptors.
In Vitro

Taurolithocholic acid (TLCA) at low concentrations (5 μM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%.TLCA (10 μM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms.
In Vivo

Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

6042-32-6
Formula Weight

505.69
Molecular Formula

C26H44NNaO5S
Purity

>98% (HPLC)
Solubility

DMSO: 20 mg/mL
SMILES

[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Chemical Name

——

1.Ha C E Petersen C E Park D S et al. Investigations of the effects of ethanol on warfarin binding to human serum albumin[J]. 2000 7(2):114-121.

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